The preceding * indicates the product approval was based upon an NCI sponsored IND.

Alkylating Agents-12

Mechlorethamine (Mustargen) (1949)
TEM (1953)
Busulfan (Myleran) (1954)
*Chlorambucil(Leukeran) (1957)
*Cyclophosphamide (Cytoxan) (1959)
*Thiotepa (1959)
Uracil Mustard (1962)
*Melphalan (L-PAM, Alkeran) (1959)
Pipobroman (Vercyte) (1966)
*Streptozotocin (Zanosar) (1982)
*Ifosfamide (Ifex) (1988)
*Melphalan (IV) (1993)

Antimetabolites-9

*Mercaptopurine (6-MP) (1953)
*Methotrexate (1953)
Fluorouracil (5-FU) (1962)
*Thioguanine (6-TG) (1966)
*Cytosine Arabinoside (Ara-C) (1969)
*FUDR (1970)
*Fludarabine Phosphate (1991)
*Pentostatin (1991)
*Chlorodeoxyadenosine (1992)

Plant Alkaloids and Antibiotics-15

Vinblastine (Velban) (1961)
*Vincristine (Oncovin) (1963)
*Actinomycin D (Cosmegen) (1964)
*Mithramycin (Mithracin) (1970)
*Bleomycin (Blenoxane) (1973)
*Doxorubicin (Adriamycin) (1974)
*Mitomycin C (Mutamycin) (1974)
*L-Asparaginase (Elspar) (1978)
*Daunomycin (Cerubidine) (1979)
*VP-16-213 (Etoposide) (1983)
Idarubicin (Idamycin) (1990)
*VM-26 (Teniposide) (1992)
*Taxol (Paclitaxel) (1992)
Navelibine (1994)
Doxorubicin Liposome Inj. (Doxil) (1995)

Synthetics-13

*Hydroxyurea (Hydrea) (1967)
*Procarbazine (Matulane) (1969)
*o-p -DDD (Lysodren, Mitotane) (1970)
*Dacarbazine (DTIC) (1975)
*CCNU (Lomustine) (1976)
*BCNU (Carmustine) (1977)
*Cis-diamminedichloroplatinum (Cis-platin) (1978)
*Mitoxantrone (Novantrone) (1988)
*Carboplatin (Paraplatin) (1989)
*Levamisole (Ergamisol) (1990)
*Hexamethylmelamine (Hexalen) (1990)
*All-trans retinoid Acid (Vessanoid) (1995)
*Porfimer sodium (Photofrin) (1995)

Hormones and Steroids-23

Ethinyl Estradiol (1949)
*DES (1950)
Testosterone (1950)
*Prednisone (1953)
*Fluoxymesterone (Halotestin) (1958)
*Dromostanolone (Drolban) (1961)
*Testolactone (Teslac) (1970)
Megestrol Acetate (Megace) (1971)
Tamoxifen (Nolvadex) (1978)
*Methyl Prednisolone
Methyltestosterone
*Prednisolone
Triamcinolone
Chlorotrianisene (TACE)
Hydroxyprogesterone (Delalutin)
Aminoglutethimide (Cytadren)
Estramustine (Emcyt)
Medroxyprogesterone Acetate (Depo-Provera, Provera)
Leuprolide (Lupron) (1985)
Flutamide (Eulexin( (1989)
*Zoladex (1989)
Bicalutamide (Casodex) (1995)
Anastrozole (Arimidex) (1995)

Biologicals-5

*Alpha Interferon (Intron A, Roferon-A) (1986)
*BCG (TheraCys, TICE) (1990)
*G-CSF (1991)
*GM-CSF (1991)
*Interleukin-2 (Proleukin) (1992)